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1995 - 1998 CNRS Research Associate, Université Louis Pasteur de Strasbourg (France)
1994 - 1995 Post-Doctoral Fellow, Université Louis Pasteur de Strasbourg (France)
1990 - 1994 PhD Thesis, jointly at the Massachusetts Institute of Technology, Cambridge (USA), and at the Ecole Normale Supérieure, Paris (France)
1990 B.Sc., chemistry, at the Ecole Normale Supérieure, Paris, France
Key publications
P. Mateus, N. Chandramouli, C. D. Mackereth, B. Kauffmann, Y. Ferrand, I. Huc, Allosteric recognition of homomeric and heteromeric pairs of monosaccharides by a foldamer capsule, Angew.Chem. Int. Ed.2020, 59,5797
V. Corvaglia, D. Carbajo, P. Prabhakaran, K. Ziach, P.K. Mandal, V. Dos Santos, C. Legeay, R. Vogel, V. Parissi, P. Pourquier, I. Huc, Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins, Nucleic Acids Res.2019, 47, 5511
J. M. Rogers, S. Kwon, S. J. Dawson, P. K. Mandal, H. Suga, I. Huc, Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids, Nat. Chem.2018, 10, 405
S. De, B. Chi, T. Granier, T. Qi, V. Maurizot, I. Huc, Designing cooperatively folded abiotic uni- and multimolecular helix bundles, Nat. Chem.2018, 10, 51
K. Ziach, C. Chollet, V. Parissi, P. Prabhakaran, M. Marchivie, V. Corvaglia, P. P. Bose, K. Laxmi-Reddy, F. Godde, J.-M. Schmitter, S. Chaignepain, P. Pourquier, I. Huc, Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA, Nat. Chem.2018, 10, 511
Q. Gan, X. Wang, B. Kauffmann, F. Rosu, Y. Ferrand, I. Huc, Translation of rod-like template sequences into homochiral assemblies of stacked helical oligomers, Nat. Nanotech.2017, 12, 447
N. Chandramouli, Y. Ferrand, G. Lautrette, B. Kauffmann, C. D.Mackereth, M. Laguerre, D. Dubreuil, I. Huc, Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose, Nat. Chem.2015, 7, 334
J. Buratto, C. Colombo, M. Stupfel, S. J. Dawson, C. Dolain, B. Langlois d'Estaintot, L. Fischer, T. Granier, M. Laguerre, B. Gallois, I. Huc, Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Angs. resolution, Angew. Chem. Int. Ed.2014, 53, 883
Q. Gan, Y. Ferrand, C. Bao, B. Kauffmann, A. Grélard, H. Jiang, I. Huc, Helix-rod host-guest complexes with shuttling rates much faster than disassembly, Science2011, 331, 1172
G. Guichard, I. Huc, Synthetic foldamers, Chem. Commun.2011, 47, 5933
I. Huc, Aromatic oligoamide foldamers, Eur. J. Org. Chem.2004, 17
H. Jiang, J.-M. Léger, I. Huc, Aromatic delta-peptides, J. Am. Chem. Soc.2003, 125, 3448