Publications Miriam Höhn

Papers

Steffens RC, Thalmayr S, Weidinger E, Seidl J, Folda P, Höhn M, Wagner E. (2024) Modulating efficacy and cytotoxicity of lipoamino fatty acid nucleic acid carriers using disulfide or hydrophobic spacers, Nanoscale 2024 Jul 25;16(29):13988-14005
Yazdi M, Pöhmerer J, Hasanzadeh Kafshgari M, Seidl J, Grau M, Höhn M, Vetter V, Hoch CC, Wollenberg B, Multhoff G, Bashiri Dezfouli A, Wagner E (2024) In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting. Small 2024 Jun 25:e2400643
Zhang F, Burghardt T, Höhn M, Wagner E (2024) Dual Effect by Chemical Electron Transfer Enhanced siRNA Lipid Nanoparticles: Reactive Oxygen Species-Triggered Tumor Cell Killing Aggravated by Nrf2 Gene Silencing.Pharmaceutics 2024 Jun 7;16(6):779
Germer J, Lessl AL, Pöhmerer J, Grau M, Weidinger E, Höhn M, Yazdi M, Cappelluti MA, Lombardo A, Lächelt U, Wagner E. (2024) Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 Based Gene Editing at Ultra-Low Dose. J. Control. Release 2024 Jun:370:239-255
Steffens RC, Folda P, Fendler NL, Höhn M, Bücher-Schossau K, Kempter S, Snyder NL, Hartmann L, Wagner E, Berger S. (2024) GalNAc- or Mannose-PEG-Functionalized Polyplexes Enable Effective Lectin-Mediated DNA Delivery, Bioconjug Chem. 2024 Mar 20;35(3):351-370
Lyu M, Yazdi M, Lin Y, Höhn M, Lächelt U, Wagner E. (2024) Receptor-Targeted Dual pH-Triggered Intracellular Protein Transfer. ACS Biomater Sci Eng. 2024 Jan 8;10(1):99-114
Haase F, Pöhmerer J, Yazdi M, Grau M, Zeyn Y, Wilk U, Burghardt T, Höhn M, Hieber C, Bros M, Wagner E, Berger S. (2024) Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity. Eur. J. Pharm. Biopharm. 2024:194, 95–109
Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U. (2023) mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates, Bioconjug. Chem. 2023 Dec 20;34(12):2263-2274
Öztürk Ö, Lessl AL, Höhn M, Wuttke S, Nielsen PE, Wagner E, Lächelt U. (2023) Peptide nucleic acid-zirconium coordination nanoparticles, Sci Rep. 2023 Aug 30;13(1):14222
Thalmayr S, Grau M, Peng L, Pöhmerer J, Wilk U, Folda P, Yazdi M, Weidinger E, Burghardt T, Höhn M, Wagner E, Berger S. (2023) Molecular Chameleon Carriers for Nucleic Acid Delivery: The Sweet Spot between Lipoplexes and Polyplexes, Adv. Mater. 2023 Jun;35(25):e2211105
Shen, F., Lin, Y., Höhn, M., Luo, X., Döblinger, M., Wagner, E., Lächelt, U. (2023) Iron-gallic acid peptide nanoparticles as versatile platform for cellular delivery with synergistic ROS enhancement effect, Pharmaceutics 2023 Jun 21;15(7):1789
LinY., Luo, X., Burghardt, T., Dörrer, S., Höhn, M., Wagner, E., Lächelt, U. (2023) Chemical evolution of amphiphilic xenopeptides for potentiated Cas9 ribonucleoprotein delivery, J Am Chem Soc. 2023 Jul 19;145(28):15171-15179
Zhang F, Lin Y, Höhn M, Wagner E. (2023) Chemical-electron-transfer-based lipopolyplexes for enhanced siRNA delivery, Cell Reports Physical Science 4, 101444, Jun 21, 2023
Lin Y, Wilk U, Pöhmerer J, Hörterer E, Höhn M, Luo X, Mai H, Wagner E, Lächelt U. (2023) Folate receptor-mediated delivery of Cas9 RNP for enhanced immune checkpoint disruption in cancer cells, Small. 2023 Jan;19(2):e2205318
Lyu M, Yazdi M, Lin Y, Höhn M, Lächelt U, Wagner E. (2022) Receptor-Targeted Dual pH-Triggered Intracellular Protein Transfer, ACS Biomater Sci Eng. 2022 Jul 8. doi: 10.1021/acsbiomaterials.2c00476. Online ahead of print
Luo, J., Schmaus, J., Cui, M., Hörterer, E., Wilk, U., Höhn, M., Däther, M., Berger, S., Benli-Hoppe, T., Peng, L., Wagner, E. (2021) Hyaluronate siRNA nanoparticles with positive charge display rapid attachment to tumor endothelium and penetration into tumors, J Control Release 2021 Jan 10;329:919-933
Hirschle, P., Hirschle, C., Böll, K., Döblinger, M., Höhn, M., Tuffnell, J.M., Ashling, C.W., Keen, D.A., Bennett, T.D., Rädler, J.O., Wagner, E., Peller, M., Lächelt, U., Wuttke, S. (2020) Tuning the Morphological Appearance of Iron(III) Fumarate: Impact on Material Characteristics and Biocompatibility, Chem. Mater. 2020, 32, 6, 2253-2263
Kuhn J, Lin Y, Krhac Levacic A, Al Danaf N, Peng L, Höhn M, Lamb DC, Wagner E, Lächelt U (2020) Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides, Bioconjug Chem. 2020 Mar 18;31(3):729-742
Wang, Y. Luo, J., Truebenbach, I., Reinhard, S., Klein, P., Hoehn, M., Kern, S., Morys, S., Loy, D., Wagner, E., Zhang, W. (2020) Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells, ACS Biomater. Sci. Eng. 2020, 6, 2, 1074-1089
Kuhn, J., Klein, P. M., Al Danaf, N., Nordin, J. Z., Reinhard, S., Loy, D. M., Höhn, M., El Andaloussi, S., Lamb, D. C., Wagner, E., Aoki, Y., Lehto, T., Lächelt, U. (2019) Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles, Adv. Funct. Mater. 2019, 1906432
Steinborn, B., Hirschle, P., Höhn, M., Bauer, T., Barz, M., Wuttke, S., Wagner, E., Lächelt, U. (2019) Core-Shell Functionalized Zirconium-Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content, Adv Therapeutics 2019, 1900120
Truebenbach, I., Zhang, W., Wang, Y., Kern, S., Höhn, M., Reinhard, S., Gorges, J., Kazmaier, U., Wagner, E. (2019) Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells, Int J Pharm. 2019 Oct 5;569:118570
Truebenbach, I., Kern, S., Loy, D.M., Hoehn, M., Gorges, J., Kazmaier, U., Wagner E. (2019) Combination chemotherapy of L1210 tumors in mice with pretubulysin and methotrexate nanoparticles, Mol Pharm. 2019 Jun 3;16(6):2405-2417
Luo, J., Höhn, M., Reinhard, S., Loy, D.M., Klein, P.M., Wagner, E. (2019) IL4-receptor-targeted dual antitumoral apoptotic peptide - siRNA conjugate lipoplexes, Adv. Funct. Materials 29 (25), 1900697
Zimpel, A., Al Danaf, N., Steinborn, B., Kuhn, J., Höhn, M., Bauer, T., Hirschle, P., Schrimpf, W., Engelke, H., Wagner, E., Barz, M., Lamb, D.C., Lächelt, U., Wuttke, S. (2019) Coordinative binding of polymers to metal-organic framework nanoparticles for control of interactions at the biointerface, ACS Nano. 2019 Apr 23;13(4):3884-3895
Kern, S., Truebenbach, I., Höhn, M., Gorges, J., Kazmaier, U., Zahler, S., Vollmar, A. M., Wagner, E. (2019) Combined antitumoral effects of pretubulysin and methotrexate, Pharmacol Res Perspect. 2019 Jan 22;7(1):e00460
Klein, P.M., Kern, S., Lee, D.J., Schmaus, J., Höhn, M., Gorges, J., Kazmaier, U., Wagner, E. (2018) Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo, Biomaterials. 2018 Sep;178:630-642
Röder, R., Preiß, T., Hirschle, P., Steinborn, B., Zimpel, A., Höhn, M., Rädler, J.O., Bein, T., Wagner, E., Wuttke, S., Lächelt, U. (2017) Multifunctional Nanoparticles by Coordinative Self-Assembly of His-Tagged Units with Metal-Organic Frameworks, J Am Chem Soc. 2017 Feb 15;139(6):2359-2368
Müller, K., Kessel, E., Klein, P.M., Höhn, M., Wagner, E. (2016) Post-PEGylation of siRNA lipo-oligoamino amide polyplexes using tetra-glutamylated folic acid as ligand for receptor-targeted delivery, Mol Pharm. 2016 Jul 5;13(7):2332-45
Zhang, W., Müller, K., Kessel, E., Reinhard, S., He, D., Klein, P.M., Höhn, M., Rödl, W., Kempter, S., Wagner, E. (2016) Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nano-Core with an Influenza Peptide and Transferrin Shell, Adv Healthc Mater. 2016 Jun;5(12):1493-504

Klein PM, Müller K, Gutmann C, Kos P, Krhac Levacic A, Edinger D, Höhn M, Leroux JC, Gauthier MA, Wagner E (2015) Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes, J Control Release. 2015 May 10;205:109-19

Lächelt U, Wittmann V, Müller K, Edinger D, Kos P, Höhn M, Wagner E (2014) Synthetic Polyglutamylation of Dual-Functional MTX Ligands for Enhanced Combined Cytotoxicity of Poly(I:C) Nanoplexes, Mol Pharm. 2014 Aug 4;11(8):2631-9
Thoenes, L., Höhn, M., Kashirin, R., Ogris, M., Arnold, G.J., Wagner, E., Günther, M. (2010) In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy, J Proteomics. 2010 May 7;73(7):1342-54

Landshamer, S., Höhn, M., Barth, N., Duvezin-Caubet, S., Schwake, G., Tobaben, S., Kazhdan, I., Becattini, B., Zahler, S., Vollmar, A., Pellecchia, M., Reichert, A., Plesnila, N., Wagner, E., Culmsee, C. (2008) Bid-induced release of AIF from mitochondria causes immediate neuronal cell death, Cell Death Differ. 2008 Oct;15(10):1553-63